She is the wife of pharmaceutical mogul Dr. Phillip Frost, the doctor-turned-business genius behind the Key and then IVAX Corporation generic drug empires, who bought interests in everything from sports memorabilia to biotech operations to cell-phone technology to a cigarette company. Simply announcing his purchases has sent stocks skyrocketing as much as 50 percent within hours.

Frost is one-half of a potent philanthropy duo that not only gave $33 million to breathe life into the University of Miami’s School of Music (one of the largest single gifts ever given to the music school), but also donated $3 million to the Florida International University art museum — another arts institution that now bears the Frost name.

Frost retired after serving 20 years as principal of Henry West Laboratory Elementary School, a professional development school run by UM and Miami-Dade County Schools. The generous woman, who now lists her occupation as “homemaker,” and her husband share a $47 million home on Star Island, a $60 million private jet and a love of giving.

With that title, according to reports, she contributed $5,000 to a political action committee in the congressional district of a co-subcommittee member of Democrat Peter Deutsch — a sponsor of the Prescription Drug Competition Act of 2000, which sought to allow greater availability of generic drugs. Plus, her husband has reportedly given more than $450,000 in soft money contributions to the Democratic Party, often maxing out legal contributions to Deutsch and other allies.

Frost is the chair of the Smithsonian National Board and the commissioner emeritus of the Smithsonian American Art Museum, which has received more than 152 art pieces from Frost donations. She serves on the FIU Board of Trustees and is a past chair of the FIU Foundation.